Simultaneous Determination of Dapsone and Pyrimethamine by Derivative Spectrophotometry in Pharmaceutical Formulations
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Simultaneous Determination of Losartan and Hydrochlorothiazide in Pharmaceutical Preparations by Derivative and Ratio Derivative Spectrophotometry
Background & Aims: Losartan is a non-peptide potent antihypertensive agent that acts through blocking angiotensin II receptors. Hyzaar® is a combination product that contains two drugs, losartan and hydrochlorothiazide, used to lower high blood pressure. There are some reports regarding simultaneous measurement of the drugs in pharmaceutical and biological samples which includes HPLC, CE, CEC, ...
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Losartan, a highly effective blood pressure lowering agent, has been widely used for the treatment of hypertension. A fast and reliable method for the determination of losartan was highly desirable to support formulation screening and quality control. A first derivative UV spectroscopic method was developed for determination of losartan in the tablet dosage form. The first derivative spectrum r...
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A method for determination of alendronate sodium salt, clodronate disodium salt and etidronate disodium salt in pharmaceutical formulation by direct UV-spectrophotometry and/or first and second derivative UV-spectrophotometry via complex formation with Cu (II) ions is described. The calibration graphs are linear in the range 25-600 mmol/L for all the investigated compounds. No interference was ...
متن کاملSimultaneous Determination of Potassium Clavulanate and Amoxicillin Trihydrate in Bulk, Pharmaceutical Formulations and in Human Urine Samples by UV Spectrophotometry
A simple and sensitive UV spectrophotometric method was developed and validated for the simultaneous determination of Potassium Clavulanate (PC) and Amoxicillin Trihydrate (AT) in bulk, pharmaceutical formulations and in human urine samples. The method was linear in the range of 0.2-8.5 μg/ml for PC and 6.4-33.6 μg/ml for AT. The absorbance was measured at 205 and 271 nm for PC and AT respectiv...
متن کاملSimultaneous Determination and Classification of Riboflavin, Thiamine, Nicotinamide and Pyridoxine in Pharmaceutical Formulations, by UV-Visible Spectrophotometry and Multivariate Analysis
Soft Independent Modeling of Class Analogy (SIMCA) e Regressão por Mínimos Quadrados Parciais foram usados nesse trabalho para a identificação e quantificação de tiamina, riboflavina, nicotinamida e piridoxina, por espectrofotometria UV-Vis, sem realizar os procedimentos analíticos de separação e pré-concentração. Para a quantificação, os intervalos de trabalho estabelecidos foram 1-14 mg L par...
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ژورنال
عنوان ژورنال: Journal of AOAC INTERNATIONAL
سال: 2003
ISSN: 1060-3271,1944-7922
DOI: 10.1093/jaoac/86.2.241